The present study, aims to evaluate the antidiabetic potential of ethanol extract of A.aspera Linn. Against alloxan induced diabetic rats. Wistar strain of albino rats of either sex were divided into five groups comprising of six rats each. Group I served as normal control, group II served as disease control (alloxan induced), group III & IV animals, received ethanol extract of A.aspera Linn leaf and callus at a dosage of 250 mg/kg body weight for 45 days, groupV served as standard drug control (glibenclamide1mg/Kg body weight). After the experimental period the blood and tissue samples were collected and subjected to various biochemical and enzymic parameters. There were profound alteration in fasting blood glucose, serum insulin, glycosylated hemoglobin (HbA1C) and liver glycogen levels in alloxanized rats. Total protein, albumin, globulin, urea level were also altered in diabetic rats. The alterations were observed to resume (P<0.05) back to normal on treatment with plant drug. The effect of plant extract was found to be dose dependent. The present investigation reveals the antidiabetic potential of ethanol extract of leaf and callus of A.aspera L
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